Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers.

ABSTRACT: It is currently not known whether most lung cancers detected by computerized tomography (CT) screening are aggressive and likely to be fatal if left untreated, or if a sizable fraction are indolent and unlikely to cause death during the natural lifetime of the individual. We developed a longitudinal biologically-based model of the relationship between individual smoking histories and the probability for lung cancer incidence, CT screen detection, lung cancer mortality, and other-cause mortality. The longitudinal model relates these different outcomes to an underlying lung cancer disease pathway and an effective other-cause mortality pathway, which are both influenced by the individual smoking history. The longitudinal analysis provides additional information over that available if these ou

SUBMITTER: Hazelton WD 

PROVIDER: S-EPMC3412888 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature