Genetic influences on developmental smoking trajectories.

ABSTRACT:

Aims

To investigate the relative contribution of genetic and environmental factors on smoking trajectory membership and to test whether individual smoking trajectories represent phenotypical thresholds of increasing genetic risk along a common genetic liability dimension.

Design

Prospective study of a birth cohort of female like-sex twin pairs.

Setting

Participants completed diagnostic interview surveys four times from adolescence (average age 16) to young adulthood (average age 25).

Participants

Female twins who had smoked ≥100 cigarettes life-time (n = 1466 regular smokers).

Measurements

Number of cigarettes smoked per day during the heaviest period of smoking (two waves) or during the past 12 months (two waves).

Findings

A four-trajectory class

SUBMITTER: Lessov-Schlaggar CN 

PROVIDER: S-EPMC3412932 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature