OLE RNA protects extremophilic bacteria from alcohol toxicity.

ABSTRACT: OLE (Ornate, Large, Extremophilic) RNAs represent a recently discovered non-coding RNA class found in extremophilic anaerobic bacteria, including certain human pathogens. OLE RNAs exhibit several unusual characteristics that indicate a potentially novel function, including exceptionally high expression and localization to cell membranes via interaction with a protein partner called OLE-associated protein (OAP). In the current study, new genetic and phenotypic characteristics of OLE RNA from Bacillus halodurans C-125 were established. OLE RNA is transcribed at high levels from its own promoter under normal growth conditions and the transcript is exceptionally stable compared to most other RNAs. Expression is increased by ∼ 7-fold when cells are exposed to near lethal concentrations of short

SUBMITTER: Wallace JG 

PROVIDER: S-EPMC3413148 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature