Lack of association of SNP rs4236601 near CAV1 and CAV2 with POAG in a Saudi cohort.

ABSTRACT:

Purpose

To determine the role of the recently discovered primary open angle glaucoma (POAG) single nucleotide polymorphism (SNP) rs4236601 near the caveolin-1 (CAV1) and CAV2 among patients and controls from Saudi Arabia.

Methods

A cohort of 220 POAG patients and 405 control subjects from Saudi Arabia were genotyped for a SNP (rs4236601;g.2891 G>A) in the chromosome 7q31 locus near CAV1 and CAV2 using a standard polymerase chain reaction (PCR) and sequencing method.

Results

The minor allele frequency (MAF) of rs4236601 was 0.3 in controls and 0.31 in POAG patients. We detected no statistical difference when we compared the allele frequencies between POAG patients and control subjects (p=0.699). Similarly, we detected no statistical difference in the frequency of the t

SUBMITTER: Abu-Amero KK 

PROVIDER: S-EPMC3413415 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature