Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.

ABSTRACT:

Objective

To investigate the associations of complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.

Methods

The study cohort consisted of a total of 95 Chinese non-infectious uveitis patients, including 38 patients with intermediate uveitis (IU), 38 patients with Vogt-Koyanagi-Harada disease (VKH), and 19 patients with Behçet's disease and 308 healthy controls. The genotypes of CFH-rs800292, KIAA1109-rs4505848, and IL27-rs4788084 were determined using TaqMan single nucleotide polymorphism genotyping assays.

Results

The frequency of carriers of G allele for CFH-rs800292 was significantly higher in patients with non-infectious intermediate and posterior uveitis than in contro

SUBMITTER: Yang MM 

PROVIDER: S-EPMC3413425 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature