A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouse.

ABSTRACT:

Background

Mouse is widely used in animal testing of cardiovascular disease. However, a large number of cardiovascular drugs that have been experimentally proved to work well on mouse were withdrawn because they caused adverse side effects in human.

Methods

In this study, we investigate whether binding patterns of withdrawn cardiovascular drugs are conserved between mouse and human through computational dockings and molecular dynamic simulations. In addition, we also measured the level of conservation of gene expression patterns of the drug targets and their interacting partners by analyzing the microarray data.

Results

The results show that target proteins of withdrawn cardiovascular drugs are functionally conserved between human and mouse. However, all the binding p

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3413526 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature