The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD.

ABSTRACT:

Background

This study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD.

Methods

One hundred and eighteen children with ADHD performed three working memory measures taken from the CANTAB battery (Spatial Span, Delayed-match-to-sample, and Spatial Working Memory). Associations between performance on working memory measures and allelic variation in catecholamine genes (including those for the noradrenaline transporter [NET1], the dopamine D4 and D2 receptor genes [DRD4; DRD2], the gene encoding dopamine beta hydroxylase [DBH] and catechol-O-methyl transferase [COMT]) were investigated using regression models that controlled for age, IQ, gender and medication status

SUBMITTER: Matthews N 

PROVIDER: S-EPMC3413539 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature