Individual participant data meta-analysis of prognostic factor studies: state of the art?

ABSTRACT:

Background

Prognostic factors are associated with the risk of a subsequent outcome in people with a given disease or health condition. Meta-analysis using individual participant data (IPD), where the raw data are synthesised from multiple studies, has been championed as the gold-standard for synthesising prognostic factor studies. We assessed the feasibility and conduct of this approach.

Methods

A systematic review to identify published IPD meta-analyses of prognostic factors studies, followed by detailed assessment of a random sample of 20 articles published from 2006. Six of these 20 articles were from the IMPACT (International Mission for Prognosis and Analysis of Clinical Trials in traumatic brain injury) collaboration, for which additional information was also used from

SUBMITTER: Abo-Zaid G 

PROVIDER: S-EPMC3413577 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature