Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis.

ABSTRACT:

Objectives

To evaluate the risk of venous thromboembolic events associated with the use of progestin-only contraception and whether that risk differs with the mode of drug delivery (oral, intrauterine, or depot injection).

Design

Systematic review and meta-analysis of randomised controlled trials and observational studies.

Data sources

Pubmed, Embase, Cochrane Library, and reference lists of relevant reviews.

Study selection

Randomised controlled trials and case-control, cohort, and cross sectional studies with venous thromboembolic outcome for progestin-only contraception reported relative to a non-hormone comparator group.

Data extraction

Data were extracted by two independent investigators, and consensus for inclusion was reached after assessment by a

SUBMITTER: Mantha S 

PROVIDER: S-EPMC3413580 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature