TP53 mutation, epithelial-mesenchymal transition, and stemlike features in breast cancer subtypes.

ABSTRACT: Altered p53 protein is prevalently associated with the pathologic class of triple-negative breast cancers and loss of p53 function has recently been linked to the induction of an epithelial-mesenchymal transition (EMT) and acquisition of stemness properties. We explored the association between TP53 mutational status and expression of some genes involved in the canonical TGF-β signaling pathway (the most potent EMT inducer) and in two early EMT associated events: loss of cell polarity and acquisition of stemness-associated features. We used a publicly accessible microarray dataset consisting of 251 p53-sequenced primary breast cancers. Statistical analysis indicated that mutant p53 tumors (especially those harboring a severe mutation) were consistent with the aggressive class of triple-nega

SUBMITTER: Coradini D 

PROVIDER: S-EPMC3414214 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature