Interleukin-4 receptor -3223T→C polymorphism is associated with increased gastric adenocarcinoma risk.

ABSTRACT:

Background

Gastric cancer remains one of the most common types of cancer worldwide, with a large geographical variation in incidence and mortality rates. Cytokine polymorphisms are the most studied host polymorphisms and are associated with an increased risk of stomach cancer in many regions, but have not been studied extensively in Eastern European populations.

Objective

To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.

Methods

A total of 347 subjects, consisting of 105 patient

SUBMITTER: Burada F 

PROVIDER: S-EPMC3414475 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature