Kinetics of atrial repolarization alternans in a free-behaving ovine model.

ABSTRACT:

Unlabelled

Kinetics of Atrial Repolarization Alternans.

Introduction

Repolarization alternans (Re-ALT), a beat-to-beat alternation in action potential repolarization, promotes dispersion of repolarization, wavebreaks, and reentry. Recently, Re-ALT has been shown to play an important role in the transition from rapid pacing to atrial fibrillation (AF) in humans. The detailed kinetics of atrial Re-ALT, however, has not been reported so far. We developed a chronic free-behaving ovine pacing model to study the kinetics of atrial Re-ALT as a function of pacing rate.

Methods

Thirteen sheep were chronically implanted with 2 pacemakers for the recording of broadband right atrial unipolar electrograms and delivery of rapid pacing protocols. Beat-to-beat differences in the atri

SUBMITTER: Jousset F 

PROVIDER: S-EPMC3414656 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature