Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.

ABSTRACT: The hippocampus undergoes changes with aging that impact neuronal function, such as synapse loss and altered neurotransmitter release. Nearly half of the aged population also develops deficits in spatial learning and memory. To identify age-related hippocampal changes that may contribute to cognitive decline, transcriptomic analysis of synaptosome preparations from adult (12 months) and aged (28 months) Fischer 344-Brown Norway rats assessed for spatial learning and memory was performed. Bioinformatic analysis identified the MHCI pathway as significantly upregulated with aging. Age-related increases in mRNAs encoding the MHCI genes RT1-A1, RT1-A2, and RT1-A3 were confirmed by qPCR in synaptosomes and in CA1 and CA3 dissections. Elevated levels of the MHCI cofactor (B2m), antigen-loading co

SUBMITTER: VanGuilder Starkey HD 

PROVIDER: S-EPMC3414657 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature