Large-scale replication and heterogeneity in Parkinson disease genetic loci.

ABSTRACT:

Objective

Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

Methods

Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium were invited to participate in the study. A total of 11 SNPs were genotyped in 8,750 cases and 8,955 controls. Fixed as well as random effects models were used to provide the summary risk estimates for these variants. We evaluated between-study heterogeneity and heterogeneity between populations of different ancestry.

Results

In the overall analysis, single nucleotide polymorphisms (SNPs) in 9

SUBMITTER: Sharma M 

PROVIDER: S-EPMC3414661 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature