Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi.

ABSTRACT:

Background

Brugia malayi is a nematode parasite that causes lymphatic filariasis, a disfiguring and disabiling tropical disease. Although a first draft genome sequence was released in 2007, very little is understood about transcription programs that govern developmental changes required for the parasite's development and survival in its mammalian and insect hosts.

Results

We used a microarray with probes that represent some 85% of predicted genes to generate gene expression profiles for seven parasite life cycle stages/sexes. Approximately 41% of transcripts with detectable expression signals were differentially expressed across lifecycle stages. Twenty-six percent of transcripts were exclusively expressed in a single parasite stage, and 27% were expressed in all stages stud

SUBMITTER: Li BW 

PROVIDER: S-EPMC3414817 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature