Plasma markers for identifying patients with metastatic melanoma.

ABSTRACT:

Purpose

With the rising incidence of melanoma, more patients are undergoing surveillance for disease recurrence. Our purpose was to study levels of proteins that might be secreted in the blood of patients with metastatic melanoma that can be used for monitoring these individuals.

Methods

Genome-wide gene expression data were used to identify abundantly expressed genes in melanoma cells that encode for proteins likely to be present in the blood of cancer patients, based on high expression levels in tumors. ELISA assays were employed to measure proteins in plasma of 216 individuals; 108 metastatic melanoma patients and 108 age- and gender-matched patients with resected stage I/II disease split into equal-sized training and test cohorts.

Results

Levels of seven markers,

SUBMITTER: Kluger HM 

PROVIDER: S-EPMC3415234 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature