Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise.

ABSTRACT:

Background

Exercise oscillatory ventilation (EOV) is a noninvasive parameter that potently predicts outcomes in systolic heart failure (HF). However, mechanistic insights into EOV have been limited by the absence of studies relating EOV to invasive hemodynamic measurements and blood gases performed during exercise.

Methods and results

Fifty-six patients with systolic HF (mean±SEM age, 59±2 years; left ventricular ejection fraction, 30±1%) and 19 age-matched control subjects were studied with incremental cardiopulmonary exercise testing. Fick cardiac outputs, filling pressures, and arterial blood gases were measured at 1-minute intervals during exercise. We detected EOV in 45% of HF (HF+EOV) patients and in none of the control subjects. The HF+EOV group did not differ from th

SUBMITTER: Murphy RM 

PROVIDER: S-EPMC3415253 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature