Genomic patterns of homozygosity in worldwide human populations.

ABSTRACT: Genome-wide patterns of homozygosity runs and their variation across individuals provide a valuable and often untapped resource for studying human genetic diversity and evolutionary history. Using genotype data at 577,489 autosomal SNPs, we employed a likelihood-based approach to identify runs of homozygosity (ROH) in 1,839 individuals representing 64 worldwide populations, classifying them by length into three classes-short, intermediate, and long-with a model-based clustering algorithm. For each class, the number and total length of ROH per individual show considerable variation across individuals and populations. The total lengths of short and intermediate ROH per individual increase with the distance of a population from East Africa, in agreement with similar patterns previously observ

SUBMITTER: Pemberton TJ 

PROVIDER: S-EPMC3415543 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature