Ontology highlight
ABSTRACT:
SUBMITTER: Stadler ZK
PROVIDER: S-EPMC3415553 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
American journal of human genetics 20120802 2
Although heritable factors are an important determinant of risk of early-onset cancer, the majority of these malignancies appear to occur sporadically without identifiable risk factors. Germline de novo copy-number variations (CNVs) have been observed in sporadic neurocognitive and cardiovascular disorders. We explored this mechanism in 382 genomes of 116 early-onset cancer case-parent trios and unaffected siblings. Unique de novo germline CNVs were not observed in 107 breast or colon cancer tri ...[more]