Epidemiologic consequences of microvariation in Mycobacterium tuberculosis.

ABSTRACT:

Background

Evidence from genotype-phenotype studies suggests that genetic diversity in pathogens have clinically relevant manifestations that can impact outcome of infection and epidemiologic success. We studied 5 closely related Mycobacterium tuberculosis strains that collectively caused extensive disease (n = 862), particularly among US-born tuberculosis patients.

Methods

Representative isolates were selected using population-based genotyping data from New York City and New Jersey. Growth and cytokine/chemokine response were measured in infected human monocytes. Survival was determined in aerosol-infected guinea pigs.

Results

Multiple genotyping methods and phylogenetically informative synonymous single nucleotide polymorphisms showed that all strains were related b

SUBMITTER: Mathema B 

PROVIDER: S-EPMC3415951 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature