Predicting three-dimensional structures of transmembrane domains of β-barrel membrane proteins.

ABSTRACT: β-Barrel membrane proteins are found in the outer membrane of gram-negative bacteria, mitochondria, and chloroplasts. They are important for pore formation, membrane anchoring, and enzyme activity. These proteins are also often responsible for bacterial virulence. Due to difficulties in experimental structure determination, they are sparsely represented in the protein structure databank. We have developed a computational method for predicting structures of the transmembrane (TM) domains of β-barrel membrane proteins. Based on physical principles, our method can predict structures of the TM domain of β-barrel membrane proteins of novel topology, including those from eukaryotic mitochondria. Our method is based on a model of physical interactions, a discrete conformational state space, an em

SUBMITTER: Naveed H 

PROVIDER: S-EPMC3415959 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature