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The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae.

ABSTRACT: Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.

SUBMITTER: Lo TL 

PROVIDER: S-EPMC3416016 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae.

Lo Tricia L TL   Qu Yue Y   Uwamahoro Nathalie N   Quenault Tara T   Beilharz Traude H TH   Traven Ana A  

Genetics 20120517 4

Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription. ...[more]

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