Asexuals, polyploids, evolutionary opportunists...: the population genetics of positive but deteriorating mutations.

ABSTRACT: Some genetic phenomena originate as mutations that are initially advantageous but decline in fitness until they become distinctly deleterious. Here I give the condition for a mutation-selection balance to form and describe some of the properties of the resulting equilibrium population. A characterization is also given of the fixation probabilities for such mutations.

SUBMITTER: Bengtsson BO 

PROVIDER: S-EPMC3416017 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature