Differences in gene expression between strabismic and normal human extraocular muscles.

ABSTRACT:

Purpose

Strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of EOM has not been examined. Differences in gene expression may inform about causes and effects of the strabismic condition in humans.

Methods

EOM samples were obtained during corrective surgery from patients with horizontal strabismus and from deceased organ donors with normal EOMs. Microarrays and quantitative PCR identified significantly up- and down-regulated genes in EOM samples. Analysis was performed on probe sets with more than 3-fold differential expression between normal and strabismic samples, with an adjusted P value of ≤ 0.05.

Results

Microarray analysis showed that 604 genes in these samples ha

SUBMITTER: Altick AL 

PROVIDER: S-EPMC3416046 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature