Ontology highlight
ABSTRACT:
SUBMITTER: Kim JY
PROVIDER: S-EPMC3416203 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20120521 14
Histone lysine methylation and demethylation are considered critical steps in transcriptional regulation. In this report, we performed chromatin immunoprecipitation with microarray technology (ChIP-chip) analysis to examine the genome-wide occupancy of H3K9-me2 during all-trans-retinoic acid (ATRA)-induced differentiation of HL-60 promyelocytic leukemia cells. Using this approach, we found that KDM3B, which contains a JmjC domain, was downregulated during differentiation through the recruitment ...[more]