Analysis of IS1236-mediated gene amplification events in Acinetobacter baylyi ADP1.

ABSTRACT: Recombination between insertion sequence copies can cause genetic deletion, inversion, or duplication. However, it is difficult to assess the fraction of all genomic rearrangements that involve insertion sequences. In previous gene duplication and amplification studies of Acinetobacter baylyi ADP1, an insertion sequence was evident in approximately 2% of the characterized duplication sites. Gene amplification occurs frequently in all organisms and has a significant impact on evolution, adaptation, drug resistance, cancer, and various disorders. To understand the molecular details of this important process, a previously developed system was used to analyze gene amplification in selected mutants. The current study focused on amplification events in two chromosomal regions that are near one o

SUBMITTER: Cuff LE 

PROVIDER: S-EPMC3416208 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature