Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice.

ABSTRACT:

Background

Type-2 Diabetes is a major health concern in the United States and other Westernized countries, with prevalence increasing yearly. There is a need to better model and predict adverse drug reactions, drug-induced liver injury, and drug efficacy in this population. Because transporters significantly contribute to drug clearance and disposition, it is highly significant to determine whether a severe diabetes phenotype alters drug transporter expression, and whether diabetic mouse models have altered disposition of acetaminophen (APAP) metabolites.

Results

Transporter mRNA and protein expression were quantified in livers and kidneys of adult C57BKS and db/db mice, which have a severe diabetes phenotype due to a lack of a functional leptin receptor. The urinary excreti

SUBMITTER: More VR 

PROVIDER: S-EPMC3416584 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature