The evolutionary imprint of domestication on genome variation and function of the filamentous fungus Aspergillus oryzae.

ABSTRACT: The domestication of animals, plants, and microbes fundamentally transformed the lifestyle and demography of the human species [1]. Although the genetic and functional underpinnings of animal and plant domestication are well understood, little is known about microbe domestication [2-6]. Here, we systematically examined genome-wide sequence and functional variation between the domesticated fungus Aspergillus oryzae, whose saccharification abilities humans have harnessed for thousands of years to produce sake, soy sauce, and miso from starch-rich grains, and its wild relative A. flavus, a potentially toxigenic plant and animal pathogen [7]. We discovered dramatic changes in the sequence variation and abundance profiles of genes and wholesale primary and secondary metabolic pathways between d

SUBMITTER: Gibbons JG 

PROVIDER: S-EPMC3416971 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature