Ontology highlight
ABSTRACT:
SUBMITTER: Livesey KM
PROVIDER: S-EPMC3417120 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Cancer research 20120216 8
The balance between apoptosis ("programmed cell death") and autophagy ("programmed cell survival") is important in tumor development and response to therapy. Here, we show that high mobility group box 1 (HMGB1) and p53 form a complex that regulates the balance between tumor cell death and survival. We show that knockout of p53 in HCT116 cells increases expression of cytosolic HMGB1 and induces autophagy. Conversely, knockout of HMGB1 in mouse embryonic fibroblasts increases p53 cytosolic localiz ...[more]