Proteomic analysis of saliva identifies potential biomarkers for orthodontic tooth movement.

ABSTRACT: Orthodontic treatment has been shown to induce inflammation, followed by bone remodelling in the periodontium. These processes trigger the secretion of various proteins and enzymes into the saliva. This study aims to identify salivary proteins that change in expression during orthodontic tooth movement. These differentially expressed proteins can potentially serve as protein biomarkers for the monitoring of orthodontic treatment and tooth movement. Whole saliva from three healthy female subjects were collected before force application using fixed appliance and at 14 days after 0.014'' Niti wire was applied. Salivary proteins were resolved using two-dimensional gel electrophoresis (2DE) over a pH range of 3-10, and the resulting proteome profiles were compared. Differentially expressed prot

SUBMITTER: Ellias MF 

PROVIDER: S-EPMC3417200 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature