Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment.

ABSTRACT: Members of the Burkholderia cepacia complex (Bcc) are important in medical, biotechnological, and agricultural disciplines. These bacteria naturally occur in soil and water environments and have adapted to survive in association with plants and animals including humans. All Bcc species are opportunistic pathogens including Burkholderia cenocepacia that causes infections in cystic fibrosis and chronic granulomatous disease patients. The adaptation of B. cenocepacia to the host environment was assessed in a rat chronic respiratory infection model and compared to that of high cell-density in vitro grown cultures using transcriptomics. The distribution of genes differentially expressed on chromosomes 1, 2, and 3 was relatively proportional to the size of each genomic element, whereas the propo

SUBMITTER: O'Grady EP 

PROVIDER: S-EPMC3417382 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature