Genetic polymorphisms of human platelet antigens-1 to -6, and -15 in the Malaysian population.

ABSTRACT:

Background

Human platelet antigens (HPA) are determinant in several platelet-specific alloimmune disorders, such as neonatal alloimmune thrombocytopenia, post-transfusion purpura and platelet transfusion refractoriness. The distribution of HPA systems in the Malaysian population is not known. Defining the patterns of HPA systems provides a basis for risk assessment and management of the above complications.

Materials and methods

The aim of this study was to investigate the distribution of HPA -1 to -6 and -15 in the three major ethnic groups (Malay, Chinese and Indian) in the Malaysian population. A total of 600 random donor samples, 200 from each of the three ethnic groups, were genotyped by means of real time polymerase chain reaction (PCR) with hydrolysis probes and PCR-r

SUBMITTER: Tan JY 

PROVIDER: S-EPMC3417737 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature