Strong selective sweep associated with a transposon insertion in Drosophila simulans.

ABSTRACT: We know little about several important properties of beneficial mutations, including their mutational origin, their phenotypic effects (e.g., protein structure changes vs. regulatory changes), and the frequency and rapidity with which they become fixed in a population. One signature of the spread of beneficial mutations is the reduction of heterozygosity at linked sites. Here, we present population genetic data from several loci across chromosome arm 2R in Drosophila simulans. A 100-kb segment from a freely recombining region of this chromosome shows extremely reduced heterozygosity in a California population sample, yet typical levels of divergence between species, suggesting that at least one episode of strong directional selection has occurred in the region. The 5' flanking sequence of

SUBMITTER: Schlenke TA 

PROVIDER: S-EPMC341797 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature