Anatomy and evolution of telomeric and subtelomeric regions in the human protozoan parasite Trypanosoma cruzi.

ABSTRACT:

Background

The subtelomeres of many protozoa are highly enriched in genes with roles in niche adaptation. T. cruzi trypomastigotes express surface proteins from Trans-Sialidase (TS) and Dispersed Gene Family-1 (DGF-1) superfamilies which are implicated in host cell invasion. Single populations of T. cruzi may express different antigenic forms of TSs. Analysis of TS genes located at the telomeres suggests that chromosome ends could have been the sites where new TS variants were generated. The aim of this study is to characterize telomeric and subtelomeric regions of T. cruzi available in TriTrypDB and connect the sequences of telomeres to T. cruzi working draft sequence.

Results

We first identified contigs carrying the telomeric repeat (TTAGGG). Of 49 contigs identified, 45 h

SUBMITTER: Moraes Barros RR 

PROVIDER: S-EPMC3418195 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature