Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome.

ABSTRACT:

Rationale

Churg-Strauss syndrome (CSS) and hypereosinophilic syndrome (HES) overlap considerably in clinical presentation. A reliable means of distinguishing between these groups of patients is needed, especially in the setting of glucocorticoid therapy.

Methods

A retrospective chart review of 276 adult subjects referred for evaluation of eosinophilia > 1500/μl was performed, and subjects with a documented secondary cause of eosinophilia or a PDGFR -positive myeloproliferative neoplasm were excluded. The remaining subjects were assessed for the presence of American College of Rheumatology (ACR) criteria. Laboratory and clinical parameters were compared between subjects with biopsy-proven vasculitis (CSS; n = 8), ≥4 ACR criteria (probable CSS; n = 21), HES with asthma and/or

SUBMITTER: Khoury P 

PROVIDER: S-EPMC3418460 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature