Acquisition of CD4-dependence by CD4-independent SIV passaged in human peripheral blood mononuclear cells.

ABSTRACT:

Background

Chemokine receptors (CKRs), the primordial receptors for primate lentiviruses, are sufficient to mediate virus-cell fusion. Several different fusogenic CKRs and related receptors provide a broad potential host cell range, presumably advantageous for viral spread within a given infected individual, and across species. By contrast, the additional constraint of obligatory CD4 binding, just prior to CKR engagement, radically restricts potential host cells within an individual (or lymph node microenvironment), and might also limit xenotransmission, as CD4 sequences vary among primates. In spite of these potential drawbacks, CD4 dependent entry for SIV and HIV is the rule rather than the exception, and is generally thought to have evolved by selection for 1) stabilization of v

SUBMITTER: Iyengar S 

PROVIDER: S-EPMC3418575 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature