Exposure to an organometal compound stimulates adipokine and cytokine expression in white adipose tissue.

ABSTRACT:

Objective

White adipose tissue (WAT) is now considered a defined tissue capable of interactions with other organ systems. WAT role in elevating the level of systemic chronic inflammation suggests that alterations in this tissue as the result of disease or environmental factors may influence the development and progression of various obesity-related pathologies. This study investigated WAT cell-specific responses to an organometal compound, trimethyltin (TMT), to determine possible contribution to induced inflammation.

Methods

Human primary mature adipocytes and macrophage differentiated THP-1 cells were cultured in TMT presence and relative toxicities and different adipokine levels were determined. The inflammatory response was examined in TMT presence for primary cells from

SUBMITTER: Ravanan P 

PROVIDER: S-EPMC3418814 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature