Risk of post-lung transplant renal dysfunction in adults with cystic fibrosis.

ABSTRACT:

Background

Cystic fibrosis (CF) is one of the leading indications for lung transplantation. The incidence and pre-lung transplant risk factors for posttransplant renal dysfunction in the CF population remain undefined.

Methods

We conducted a cohort study using adults (≥ 18 years old) in the CF Foundation Patient Registry from 2000 to 2008 to determine the incidence of post-lung transplant renal dysfunction, defined by an estimated glomerular filtration rate of < 60 mL/min/1.73 m(2). Multivariable Cox proportional hazards modeling was used to identify independent pretransplant risk factors for post-lung transplant renal dysfunction.

Results

The study cohort included 993 adult lung transplant recipients with CF, with a median follow-up of 2 years. During the study perio

SUBMITTER: Quon BS 

PROVIDER: S-EPMC3418857 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature