Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries.

ABSTRACT:

Background

Proteins functioning in the same biological pathway tend to be transcriptionally co-regulated or form protein-protein interactions (PPI). Multiple spatially and temporally regulated events are coordinated during mitosis to achieve faithful chromosome segregation. The molecular players participating in mitosis regulation are still being unravelled experimentally or using in silico methods.

Results

An extensive literature review has led to a compilation of 196 human centromere/kinetochore proteins, all with experimental evidence supporting the subcellular localization. Sixty-four were designated as "core" centromere/kinetochore components based on peak expression and/or well-characterized functions during mitosis. By interrogating and integrating online resources, w

SUBMITTER: Tipton AR 

PROVIDER: S-EPMC3419070 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature