Estimates of genetic differentiation measured by F(ST) do not necessarily require large sample sizes when using many SNP markers.

ABSTRACT: Population genetic studies provide insights into the evolutionary processes that influence the distribution of sequence variants within and among wild populations. F(ST) is among the most widely used measures for genetic differentiation and plays a central role in ecological and evolutionary genetic studies. It is commonly thought that large sample sizes are required in order to precisely infer F(ST) and that small sample sizes lead to overestimation of genetic differentiation. Until recently, studies in ecological model organisms incorporated a limited number of genetic markers, but since the emergence of next generation sequencing, the panel size of genetic markers available even in non-reference organisms has rapidly increased. In this study we examine whether a large number of genetic

SUBMITTER: Willing EM 

PROVIDER: S-EPMC3419229 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature