FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease.

ABSTRACT:

Background

Diabetes is associated with an increased risk of cardiac microvascular disease. The mechanisms by which this damage occurs are unknown. However, research suggests that signaling through the sphingosine-1-phosphates receptor 1 and 3 (S1P1/3) by FTY720, a sphiongolipid drug that is structually similar to SIP, may play a role in the treatment on cardiac microvascular dysfunction in diabetes. We hypothesized that FTY720 might exert the cardioprotective effects of S1P1 and S1P3 viaprotein kinase C-beta (PKCβ II) signaling pathway.

Methodology/principal findings

Transthoracic echocardiography was performed to detect the change of cardiac function. Scanning and transmission electron microscope with lanthanum tracer were used to determine microvascular ultrastructure and

SUBMITTER: Yin Z 

PROVIDER: S-EPMC3419247 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature