Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.

ABSTRACT: Dendritic cells (DCs), which are known to support immune activation during infection, may also regulate immune homeostasis in resting animals. Here we show that mice lacking the ubiquitin-editing molecule A20 specifically in DCs spontaneously showed DC activation and population expansion of activated T cells. Analysis of DC-specific epistasis in compound mice lacking both A20 and the signaling adaptor MyD88 specifically in DCs showed that A20 restricted both MyD88-independent signals, which drive activation of DCs and T cells, and MyD88-dependent signals, which drive population expansion of T cells. In addition, mice lacking A20 specifically in DCs spontaneously developed lymphocyte-dependent colitis, seronegative ankylosing arthritis and enthesitis, conditions stereotypical of human infla

SUBMITTER: Hammer GE 

PROVIDER: S-EPMC3419270 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature