Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics.

ABSTRACT:

Background

Polymer nanoparticles (PNP) are becoming increasingly important in nanomedicine and food-based applications. Size and surface characteristics are often considered to be important factors in the cellular interactions of these PNP, although systematic investigations on the role of surface properties on cellular interactions and toxicity of PNP are scarce.

Results

Fluorescent, monodisperse tri-block copolymer nanoparticles with different sizes (45 and 90 nm) and surface charges (positive and negative) were synthesized, characterized and studied for uptake and cytotoxicity in NR8383 and Caco-2 cells. All types of PNP were taken up by the cells. The positive smaller PNP45 (45 nm) showed a higher cytotoxicity compared to the positive bigger PNP(90) (90 nm) particles inc

SUBMITTER: Bhattacharjee S 

PROVIDER: S-EPMC3419642 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature