Modulating the rigidity and mineralization of collagen gels using poly(lactic-co-glycolic acid) microparticles.

ABSTRACT: Extensive efforts have been made to prepare osteoconductive collagen gels for the regeneration of normal bone and the pathological examination of diseased bone; however, collagen gels are often plagued by limited controllability of their rigidity and mineral deposition. This study reports a simple but efficient strategy that tunes the mechanical properties of, and apatite formation in, collagen gels by incorporating hydrolyzable poly(lactic-co-glycolic acid) (PLGA) microparticles within the gels. The PLGA microparticles are associated with the collagen fibrils and increased both the gel's elasticity and rigidity while minimally influencing its permeability. As compared with pure collagen gels, the PLGA microparticle-filled collagen gels, termed PLGA-Col hydrogels, significantly enhanced th

SUBMITTER: DeVolder RJ 

PROVIDER: S-EPMC3419851 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature