Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis.

ABSTRACT: The cellular and molecular mechanisms that control lung homeostasis and regeneration are still poorly understood. It has been proposed that a population of cells exists in the mouse lung with the potential to differentiate into all major lung bronchioalveolar epithelium cell types in homeostasis or in response to virus infection. A new population of E-Cad/Lgr6(+) putative stem cells has been isolated, and indefinitely expanded from human lungs, harbouring both, self-renewal capacity and the potency to differentiate in vitro and in vivo. Recently, a putative population of human lung stem cells has been proposed as being c-Kit(+). Unlike Integrin-α6(+) or c-Kit(+) cells, E-Cad/Lgr6(+) single-cell injections in the kidney capsule produce differentiated bronchioalveolar tissue, while retaining

SUBMITTER: Oeztuerk-Winder F 

PROVIDER: S-EPMC3419929 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature