Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer.

ABSTRACT:

Background

The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth and survival. However, little is known regarding the clinical significance of LAT1 expression in pancreatic cancer. This study was conducted to determine the prognostic significance of LAT1 expression.

Methods

A total of 97 consecutive patients with surgically resected pathological stage I-IV pancreatic ductal adenocarcinoma were retrospectively reviewed. Tumour sections were stained by immunohistochemistry for LAT1, CD98, Ki-67 and vascular endothelial growth factor (VEGF), and microvessel density was determined by CD34 and p53.

Results

L-type amino-acid transporter 1 and CD98 were highly expressed in 52.6% (51/97) and 56.7%

SUBMITTER: Kaira K 

PROVIDER: S-EPMC3419959 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature