P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand.

ABSTRACT:

Background

The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from understood. The Fas ligand (FasL)-Fas system has been implicated in a number of pathogenic states. Here, we examined the contribution of microglia-derived FasL to brain inflammatory injury, with a focus on the potential to suppress the FasL increase by inhibition of the P2X(7)-FasL signaling with pharmacological or genetic approaches during ischemia.

Methods

The cerebral microvascular occlusion was induced by microsphere injection in experimental animals. Morphological changes in microglial cells were studied immunohistochemically. The biochemical analyses wer

SUBMITTER: Lu YM 

PROVIDER: S-EPMC3420259 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature