Functional genomic analysis of Candida glabrata-macrophage interaction: role of chromatin remodeling in virulence.

ABSTRACT: Fungal septicemia is an increasingly common complication of immunocompromised patients worldwide. Candida species are the leading cause of invasive mycoses with Candida glabrata being the second most frequently isolated Candida species from Intensive Care Unit patients. Despite its clinical importance, very little is known about the mechanisms that C. glabrata employs to survive the antimicrobial and immune response of the mammalian host. Here, to decipher the interaction of C. glabrata with the host immune cells, we have screened a library of 18,350 C. glabrata Tn7 insertion mutants for reduced survival in human THP-1 macrophages via signature-tagged mutagenesis approach. A total of 56 genes, belonging to diverse biological processes including chromatin organization and golgi vesicle tran

SUBMITTER: Rai MN 

PROVIDER: S-EPMC3420920 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature