Combining the finite element method with structural connectome-based analysis for modeling neurotrauma: connectome neurotrauma mechanics.

ABSTRACT: This article presents the integration of brain injury biomechanics and graph theoretical analysis of neuronal connections, or connectomics, to form a neurocomputational model that captures spatiotemporal characteristics of trauma. We relate localized mechanical brain damage predicted from biofidelic finite element simulations of the human head subjected to impact with degradation in the structural connectome for a single individual. The finite element model incorporates various length scales into the full head simulations by including anisotropic constitutive laws informed by diffusion tensor imaging. Coupling between the finite element analysis and network-based tools is established through experimentally-based cellular injury thresholds for white matter regions. Once edges are degraded,

SUBMITTER: Kraft RH 

PROVIDER: S-EPMC3420926 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature