A dynamic response regulator protein modulates G-protein-dependent polarity in the bacterium Myxococcus xanthus.

ABSTRACT: Migrating cells employ sophisticated signal transduction systems to respond to their environment and polarize towards attractant sources. Bacterial cells also regulate their polarity dynamically to reverse their direction of movement. In Myxococcus xanthus, a GTP-bound Ras-like G-protein, MglA, activates the motility machineries at the leading cell pole. Reversals are provoked by pole-to-pole switching of MglA, which is under the control of a chemosensory-like signal transduction cascade (Frz). It was previously known that the asymmetric localization of MglA at one cell pole is regulated by MglB, a GTPase Activating Protein (GAP). In this process, MglB specifically localizes at the opposite lagging cell pole and blocks MglA localization at that pole. However, how MglA is targeted to the le

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3420945 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature